张秀珍,刘云,徐英江,宫向红,宋向军,刘慧慧,田秀慧,刘义豪,秦华伟,王忠全,周全利,任利华.新型喹噁啉类药物在水产养殖中的有效性及安全性研究进展[J].食品安全质量检测学报,2013,4(1):38-44
新型喹噁啉类药物在水产养殖中的有效性及安全性研究进展
Effectiveness and security of the new type of quinoxalines in aquaculture
投稿时间:2013-01-30  修订日期:2013-02-07
DOI:
中文关键词:  喹噁啉类  有效性  安全性  药物代谢动力学  残留消除
英文关键词:quinoxalines  effectiveness  security  pharmacokinetics  residue elimination
基金项目:山东省科学技术发展计划项目(2012GHY11517)、国家海洋公益性行业科研专项(201105013)、烟台市科技发展计划项目(2012134)
作者单位
张秀珍 山东省海洋水产研究所; 山东省海洋生态修复重点实验室 
刘云 上海海洋大学 
徐英江 山东省海洋水产研究所; 山东省海洋生态修复重点实验室 
宫向红 山东省海洋水产研究所; 山东省海洋生态修复重点实验室 
宋向军 山东省海洋水产研究所 
刘慧慧 山东省海洋水产研究所; 山东省海洋生态修复重点实验室 
田秀慧 山东省海洋水产研究所; 山东省海洋生态修复重点实验室 
刘义豪 山东省海洋水产研究所 
秦华伟 山东省海洋水产研究所 
王忠全 山东省海洋水产研究所 
周全利 山东省海洋水产研究所 
任利华 山东省海洋水产研究所 
AuthorInstitution
ZHANG Xiu-Zhen Marine Fisheries Research Institute of Shandong Province; Shandong Provincial Key Laboratory of Restoration for Marine Ecology 
LIU Yun Shanghai Ocean University 
XU Ying-Jiang Marine Fisheries Research Institute of Shandong Province; Shandong Provincial Key Laboratory of Restoration for Marine Ecology 
GONG Xiang-Hong Marine Fisheries Research Institute of Shandong Province; Shandong Provincial Key Laboratory of Restoration for Marine Ecology 
SONG Xiang-Jun Marine Fisheries Research Institute of Shandong Province 
LIU Hui-Hui Marine Fisheries Research Institute of Shandong Province; Shandong Provincial Key Laboratory of Restoration for Marine Ecology 
TIAN Xiu-Hui Marine Fisheries Research Institute of Shandong Province; Shandong Provincial Key Laboratory of Restoration for Marine Ecology 
LIU Yi-Hao Marine Fisheries Research Institute of Shandong Province 
QIN Hua-Wei Marine Fisheries Research Institute of Shandong Province 
WANG Zhong-Quan Marine Fisheries Research Institute of Shandong Province 
ZHOU Quan-Li Marine Fisheries Research Institute of Shandong Province 
REN Li-Hua Marine Fisheries Research Institute of Shandong Province 
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中文摘要:
      喹噁啉类药物是一类人工合成的具有抗菌、促进生长作用的动物专用药, 曾被广泛应用于畜禽和水产养殖业。本类早期品种喹乙醇与卡巴氧被证明有较强的毒副作用, 已被不同程度地限制或禁止使用。近年来研制成功的新型喹噁啉类药物降低了毒性, 保留了抗菌及促生长活性, 已在畜禽养殖中广泛使用。本文对新型喹噁啉类药物的种类、有效性及安全性、代谢动力学及残留消除规律、代谢途径及标识残留物进行了综述, 为该类药物在水产养殖生产中的安全合理应用提供参考。
英文摘要:
      Quinoxalines are special man-made chemical drugs which are widely used as the antibacterial growth promoters in poultry and aquatic breeding. The early products such as olaquindox and carbadox were partly forbidden or restricted because of strong toxic and side effects. In recent years, the new developed types of quinoxalines were widely used in poultry and aquatic breeding because they could reduce the toxic effect, retain the antibacterial and promote the growth activities. This article mainly summarizes the effectiveness and security, metabolism and pharmacokinetics, residual elimination, metabolic pathway and markers of the new types of quinoxalines in various kinds of aquatic breeding in order to rationalize the medication use and to ensure the safety of aquatic products.
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