杨玉玲,王 莹,马红梅,兰 卫.德国洋甘菊总黄酮对糖尿病小鼠的降血糖作用研究[J].食品安全质量检测学报,2020,11(5):1524-1528
德国洋甘菊总黄酮对糖尿病小鼠的降血糖作用研究
Study on the hypoglycemic effect of total flavonoids from Matricaria chamomilla on diabetic mice
投稿时间:2019-11-27  修订日期:2020-03-01
DOI:
中文关键词:  德国洋甘菊  总黄酮  糖尿病  降血糖作用
英文关键词:Matricaria chamomilla  total flavonoids  diabetes  hypoglycemic effect
基金项目:新疆医科大学研究生创新创业项目资助(CXCY2018037)、自治区高校科研计划青年项目(XJEDU2017S025)
作者单位
杨玉玲 新疆医科大学中医学院 
王 莹 新疆医科大学附属中医医院 
马红梅 新疆医科大学中医学院 
兰 卫 新疆医科大学中医学院;新疆名医名方与特色方剂学实验室 
AuthorInstitution
YANG Yu-Ling College of TCM Xinjiang Medical University 
WANG Ying Affiliated Hospital of TCM of Xinjiang Medical University 
MA Hong-Mei College of TCM Xinjiang Medical University 
LAN Wei College of TCM Xinjiang Medical University;Xinjiang Key Laboratory of Famous Prescription and Science of Formulas 
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中文摘要:
      目的 研究德国洋甘菊中总黄酮对糖尿病小鼠的降血糖作用。方法 将糖尿病小鼠随机分为5组: 模型组、阳性组(盐酸二甲双胍150 mg/kg)、德国洋甘菊低(78.86 mg/kg)、中(157.73 mg/kg)、高(315.46 mg/kg)剂量组。连续灌胃给药4 w后, 测定小鼠体重、空腹血糖、糖化血清蛋白、血清胰岛素, 分别测定各组小鼠口服葡萄糖0、30、60、120 min后的血糖值, 并计算曲线下面积(area under the curve, AUC)。结果 与模型组比较, 德国洋甘菊总黄酮各剂量组小鼠体重均有增加, 差异有统计学意义(P<0.05); 德国洋甘菊总黄酮中、高剂量组小鼠空腹血糖降低, 差异有统计学意义(P<0.05); 中、高剂量组小鼠糖耐量降低, 差异有统计学意义(P<0.05); 中、高剂量组小鼠GSP水平降低, 差异有统计学意义(P<0.05); 高剂量组小鼠胰岛素增加, 差异有统计学意义(P<0.05)。结论 德国洋甘菊总黄酮对糖尿病小鼠有一定的治疗作用。
英文摘要:
      Objective To study the hypoglycemic effect of total flavonoids from Matricaria chamomilla on diabetic mice. Methods Diabetic mice were randomly divided into 5 groups: model group, the positive group (administered with metformin hydrochloride, 150 mg/kg), total flavonoids from Matricaria chamomilla low dose group (78.86 mg/kg), total flavonoids from Matricaria chamomilla medium dose group (157.73 mg/kg) and total flavonoids from Matricaria chamomilla high dose group (315.46 mg/kg). After 4 weeks, body weight, fasting blood glucose (FBG), glycosylated serum protein (GSP) and serum insulin (INS) were measured.and the blood glucose values of the mice in each group after oral glucose 0, 30, 60 and 120 min were measured respectively. The area under the curve (AUC) was calculated as the change in glucose tolerance. Results Compared to the model group, the body mass of each group had significantly different (P<0.05), FBG significantly decreased in the medium and high dose group (P<0.05), the level of glucose tolerance significantly decreased in the medium and high dose group (P<0.05), the level of GSP significantly decreased in the medium and high dose group (P<0.05), the level of INS significantly decreased in the high dose group (P<0.05). Conclusion The total flavone of Matricaria chamomilla has certain hypoglycemic effect on diabetic mice.
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