贾琦琦,何承辉.SPG膜乳化法制备田蓟苷微球[J].食品安全质量检测学报,2020,11(5):1554-1560
SPG膜乳化法制备田蓟苷微球
Preparation of tilianin microspheres by SPG membrane emulsification
投稿时间:2020-01-15  修订日期:2020-03-09
DOI:
中文关键词:  田蓟苷  粒径  星点设计-效应面法
英文关键词:tilianin  particle diameter  central compositedesign and response surface methodology
基金项目:国家自然科学基金项目(81960788)
作者单位
贾琦琦 新疆医科大学;新疆维吾尔自治区药物研究所 
何承辉 新疆维吾尔自治区药物研究所 
AuthorInstitution
JIA Qi-Qi Xinjiang Medical University;Xinjiang Uygur Autonomous Region Institute of Materia Medica 
HE Cheng-Hui Xinjiang Uygur Autonomous Region Institute of Materia Medica 
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中文摘要:
      目的 采用SPG膜乳化技术制备田蓟苷微球, 并对其理化性质进行考察。方法 以聚乳酸-羟基乙酸共聚物[poly (lactic-co-glycolic acid), PLGA]为载体, 球径、平均粒径、微球不粘黏程度为考察指标, 通过单因素以及星点设计, 筛选出制备微球的最佳工艺, 然后包载药物田蓟苷, 制备田蓟苷微球, 最后考察其理化性质。结果 经最佳工艺制得的微球平均粒径为(20.72±2.95) μm, 包封率大于70%, 载药量大于1.5%, 经扫描电镜观察, 微球表面光滑圆整, 差示热分析(differential scanning calorimeter, DSC)结果表明微球中包裹药物田蓟苷。结论 该方法简便易行, 制备的微球粒径均匀, 符合微球制备要求。
英文摘要:
      Objective To prepare tilianin microspheres by SPG membrane emulsification and characterize their physicochemical properties. Methods Using PLGA as the carrier, the diameter of the ball, the average particle size, and the degree of non-stickiness of the microspheres as the indicators of investigation, the best process for preparing microspheres was screened out by single-factor experiments and central composite design, then the drug field tilianin was encapsulated to prepare tilianin microspheres. Scanning electron microscope and differential scanning calorimeter were used to investigate the physicochemical properties. Results The average diameter of the microspheres made by the optimum process was (20.72±2.95) μm, the encapsulation efficiency was over 70%, the drug loading was over 1.5%, and the surface of the microspheres was smooth and round by scanning electron microscope. The results of differential scanning calorimeter analysis showed that tilianin was coated in microspheres. Conclusion This method is simple and convenient, the particle size of microspheres is uniform , which meets the requirements of preparation.
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